Toxic Surfs

PML Surfs into HIPPO Tumor Suppressor Pathway

Growth arrest, inhibition of cell proliferation, apoptosis, senescence, and differentiation are the most characterized effects of a given tumor suppressor response. It is becoming increasingly clear that tumor suppression results from the integrated and synergistic activities of different pathways. This implies that tumor suppression includes linear, as well as lateral, crosstalk signaling. The...

ToxiC inhalaTional injury and ToxiC indusTrial ChemiCals

Anticonvulsive drug (carbamazepine) induced toxic

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Toxic neuropathies.

Toxic neuropathies generally result in length dependent axonal neuropathy with the exception of diphtheria and a few toxic neuropathies. In spite of occurrence of diphtheria in India there is paucity of published reports on diphtheritic neuropathy. Arsenic neuropathy commonly occurs in Bengal and Bangladesh because of ground water contamination whereas in Punjab it is due to contamination of op...

Toxic mushrooms

If you have a problem, no matter how large or small, Current Biology's 'agony aunt' Amber can help. Dear Amber, I pioneered a wonderful, elegant technique that everyone used, and for a while they all looked up to me. Now, a new method has superseded mine, and I'm no longer considered important. What can I do? Dear Technical, Rejoice, science has progressed. It's left you behind, and that's too ...